13 twelvemonth after she leftGrey ’s Anatomy , Katherine Heigl let the cat out of the bag to Ellen Pompeo about her expiration from the hit serial publication and how she did n’t retrieve she was " going to get such a strong reaction " at the sentence .

Grey’s Anatomyhas become one of the most beloved and longest-running TV shows of all time. The show began in 2005 and just wrapped Season 19, with over 400 episodes and counting.

Over the course of 19 seasons,Grey’s Anatomyhas had so many iconic storylines, characters, and more — it’s hard to summarize all of the legendary TV moments this show has given us.

Of course, along the way, characters and actors have departed Seattle Grace/Grey Sloan, and those have made for some of the most impactful moments. Most recently,Ellen Pompeo left as a series regularafter playing Meredith Grey since the pilot episode.

While Ellen hasn’t left the show completely — she still provides the voiceover, and she appeared in the Season 19 finale — it was a big change for the series, and marked losing the last member of the original intern group as a series regular.

Out of the original interns, one of the most notable departures came whenKatherine Heiglleft the show as Izzie Stevens in the middle of Season 6.

At the time, Katherine’s departure came after several behind-the-scenes moments where she criticizedGrey’s Anatomy. Notably, Katherine stepped out of the 2008 Emmys race, which wasreportedlyseen as a “swipe at producers for diminishing her presence on the series.”

Katherine’s decision to leave that year’s Emmys race led to people saying she was criticizing the writers — and possiblyShonda Rhimes— and it led to a lot of hate being thrown at Katherine for years. Namely she waslabeledas “difficult” to work with.

Now, 13 years after Katherine’s lastGrey’s Anatomyepisode, she and Ellen reunited forVariety’s Actors on Actorsseries where they discussed their time onGrey’s Anatomytogether, and also everything surrounding Katherine’s departure.

“When Izzie left…there was just so much going on,” Ellen began when talking about the emotion the earlyGrey’sactors brought to their performances and how it impacted the storylines. “It’s really hard to show up on set when there’s so much…and then there wasn’t even social media. There’s so much attention.”

Looking back at that time in her life, Katherine explained the anxiety she felt at the height of herGrey’s Anatomyfame. “I was just vibrating at way too high of a level of anxiety,” she began. “For me, it’s all a bit of a blur, and it took me years to learn how to deal with that, to master it.”

Katherine said that period was also when she felt she lacked “self-confidence.” She said, “I would not trade anything for my 20s. I absolutely had no idea who I was and what I wanted and who I was supposed to be and who to make happy. Just massive lack of self-confidence. And then,Grey’shit. The success ofGrey’shit, and I felt, I think it was borrowed confidence.”

She continued, saying, “I started getting real mouthy because I did have a lot to say. And there were certain boundaries and things that I was not okay with being crossed. If you cannot stand up for yourself in this industry, very few people will stand up for you. So you better learn how to, and you better be okay with them not liking you for it.” With Ellen adding that it’s a “privilege” to even get to that place as well.

Speaking about herGrey’sdeparture and a2007 interview aboutKnocked Up, which also landed her criticism, Katherine began, “I was so naive. I got on my soapbox, and I had some things to say, and I felt really passionate about this stuff. I felt really strongly. I felt so strongly that I also got a megaphone out on my soapbox. There was no part of me that imagined a bad reaction.”

“I felt really justified in how I felt about it and where I was coming from. I’ve spent most of my life — I think most women do — being in that people-pleasing mode. It’s really disconcerting when you feel like you have really displeased everybody. It was not my intention to do so, but I had some things to say, and I didn’t think I was going to get such a strong reaction,” she continued.

Katherine also talked about how she’s often seen as “the bad guy” or the “villain,” and it’s something she’s learned to deal with. With Ellen adding that she didn’t understand until her ownmassive contract negotiation forGrey’s Anatomyand new salarylanded in the news, and she was told by her manager to be “prepared to be unpopular” because of it.

Katherine said it took years to tune out everything that was being said about her, saying, “I was in my late 20s. It took me until probably my mid-to-late-30s to really get back to tuning out all of the noise and going, ‘But who are you? Who are you without all of the opinions of who you are? Are you this bad person? Are you ungrateful? Are you unprofessional? Are you difficult?'”

She continued, “Because I was confused! I thought maybe I was. I literally believed that version, and felt such shame for such a long time, and then had to go, ‘Wait. Who am I listening to? I’m not even listening to myself. I know who I am.’ I don’t need anybody to tell me who I am.”

Looking back on Katherine’s departure, Ellen added that, at the time, Katherine was one person speaking out aboutworking conditions on set, and other things that were happening, and she was almost “ahead of [her] time” because now “the whole world gets to criticize everything and tell everybody to fuck off and it’s okay…but when [she] did it…”

“Listen, nobody likes a confident woman,” Ellen continued. “They’d rather you be a woman looking for your confidence than you actually be a confident woman because that makes them nervous. … Sweet, they can handle. Strong, they can’t.”

As a longtimeGrey’s Anatomyfan — yes, I still watch live every single Thursday — this conversation between Katherine and Ellen is one I greatly enjoyed (and didn’t realize how much I needed it).

You can watch Katherine and Ellen’s entire conversation for Variety’s Actors on Actors below:

The cast of "Grey's Anatomy" surround a multi-tiered cake celebrating 400 episodes

Variety / Viayoutu.be

Screenshots from "Grey's Anatomy" of Addison Shepherd meeting Meredith Grey as Dr. Derek Shepherd looks on. Addison says "And you must be the woman who's been screwing my husband"

Closeup of Dr. Meredith Grey smiling

Jackson saying to Meredith, "Meredith Grey studying the disease that killed her mother, that's a story; that would get funding, and funding is what cures diseases" and Meredith texting him that they're moving to Boston

Izzie hugging someone in the top photo and Izzie teary-eyed in the bottom photo

Katherine Heigl holding an Emmy

Izzie holding a man's hands at a formal event

Ellen Pompeo and Katherine Heigl interviewing each other

Izzie and Meredith having a conversation

From left to right: Izzie, Alex Karev, Christina Yang, and Meredith

Izzie tearfully snuggles up to Jeffrey Dean Morgan as Denny Duquette, who is in a hospital bed

The cast of "Grey's Anatomy" posing with their Screen Actor's Guild Awards

Izzie in her scrubs stands with her arms folded

Closeup of Katherine Heigl at a red carpet event

Katherine Heigl accepting her Emmy

Katherine Heigl and Ellen Pompeo talking to each other

Closeup of Katherine Heigl on a late-night TV talk show

Article image

Izzie and Meredith sitting on a bench as Izzie holds a drink

Katherine Heigl and Ellen Pompeo interviewing each other